immunohistochemical analysis of ki-67 expression in oral lichen planus lesions

Authors

nazanin bashardoust department of oral and maxillofacial pathology, guilan university of medical sciences, rasht, iran

shirin modabbernia department of oral and maxillofacial pathology, guilan university of medical sciences, rasht, iran

sara bagheri department of oral and maxillofacial pathology, guilan university of medical sciences, rasht, iran

atena shiva department of oral and maxillofacial pathology, dental faculty, mazandaran university of medical sciences, sari, iran.

abstract

introdouction: lichen planus is a chronic, relatively common, dermal mucosa disease. the world health organization (who) has introduced lichen planus as a premalignant condition. ki-67 is a protein that can be detected in all active phases of the cell cycle, especially in the g2 and m phases. considering the major role of ki-67 in the regulation of the cell cycle and the fact that it is one of the conditions for pre-malignant potential and epithelial proliferation, the aim of this study was to evaluate ki-67 expression in oral lichen planus (olp) lesions. materials and methods: this study included 32 patients [16 with olp and 16 with no olp and a normal epithelium, which were considered the control group (cg)]. demographic data was extracted from each patient’s file and documented in an information form. immunohistochemistry for ki-67 was conducted using the envision method. p value was significant at <0.05. results: ki-67 staining quality in the olp group was significantly greater than the cg group according to both the mann–whitney test and quantity (p = 0.001). the average percentage of positive cells in the olp group was 13.11, while the average in the cg group was 2.26. ki-67 staining in olps was 87.5% (++) and 62% with a strong degree of staining. age and gender differences were compared using the independent t-test no significant statistical differences were noted between the two groups. conclusion: considering ki-67 is a proliferation marker, the increased expression of ki-67 in the olp group’s epithelium indicates a high proliferation rate in lichen planus lesions.

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Journal title:
journal of dentomaxillofacil radiology, pathology and surgery

جلد ۴، شماره ۱، صفحات ۲۵-۳۰

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